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Blaustein Pain Grand Rounds Conference October 22, 2021

Deep Learning-Based Analysis of Macaque Corneal Sub-Basal Nerve Fibers in In Vivo Confocal Microscopy Images

This was a presentation given as part of the Blaustein Pain Grand Rounds Conferences held at Johns Hopkins University School of Medicine. It gives an overview of the collaboration between Prof. Mankowski’s lab and Voxeleron in the automated analysis of macaque corneal sub-basal nerve fibers using confocal microscopy and how the work is being transferred to clinical applications.  We also offer some intuition into how convolutional neural networks (CNNs) are actually working as these underpin our approach to automated analysis of the image data.

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Example Ccm Result Image
Example confocal microscopy image of the sub-basal nerve plexus (left), the deep learning output (middle) and the final analysis showing metrics and branch locations (right).
Cnn Meme
A slide from the talk as we discuss what CNNs are actually doing.  Reference for this slide: